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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
The peptide is unaffected
Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH
But their rise doesnt happen in isolation
Rather than turning to an unproven peptide, Midis medical experts recommend other lifestyle shifts that are immune-system powerhouses with real science behind them
PMID: 22950504
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