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The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan
This likely results from: Reduced mechanical stress from weight loss decreasing load on joints Lower systemic inflammation reducing inflammatory mediators in joint tissue Improved metabolic health reducing the metabolic component of osteoarthritis While there are no large randomized trials specifically studying semaglutide for osteoarthritis, the clinical observations are consistent and encouraging
These trials showed promising weight loss results and established the doses that work best
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However, there was no change in carotid IMT with GLP-1 RA treatment despite an improved glycemic profile and a significant adipose tissue reduction [90]
