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(2021) pilot RCT, GlyNAC supplementation in older adults reduced HOMA-IR (a marker of insulin resistance) to levels comparable to younger controls [10]
Hypotheses 153 , 110627 (2021)
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Future studies should investigate whether mitochondria-targeted interventions (e.g., exercise, NAD + precursors, mitophagy inducers) can simultaneously reduce frailty and prevent cardiometabolic-cognitive decline [40]
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