In skeletal muscle of insulin-resistant patients, mitochondrial oxidative phosphorylation (OXPHOS) capacity is reduced, BCAA catabolic enzyme expression is downregulated, leading to accumulation of BCAA metabolic intermediates such as C3 and C5 acylcarnitines (114)
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Its modified structure is designed to enhance stability and receptor interaction within controlled research environments
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This indication can unlock coverage pathways that weight management alone cannot, including Medicare Part D, which now covers at least one anti-obesity medication under the Treat and Reduce Obesity Act effective April 2026