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T2D had been associated with increased intestinal permeability, able to cause penetration of bacteria across gut barrier, resulting in metabolic endotoxaemia and determining low-grade systemic inflammation [53]

TLR4 can be stimulated also by saturated fatty acids (SFA), showing an important role of high-fat diet itself in determining systemic inflammation

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Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR): a review

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Sci Rep 6 , 37178 (2016)