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GLP-1based therapies improve glycemic control and promote weight loss, but they also appear to dampen systemic inflammation through both weight-dependent and weight-independent effects

The SURMOUNT-4 trial demonstrated that patients who discontinued tirzepatide after 36 weeks regained an average of 14% of their body weight over the subsequent 52 weeks, compared with continued weight loss in those who stayed on the drug [5]

They slow gastric emptying, increase satiety signals to the brain, and reduce the drive to overeat

This polymorphism is found in the heme biosynthesis pathway where it has been associated with altered toxicokinetics of lead levels and elevated blood levels of lead [100102]

In a study published Wednesday, researchers analyzed medical records from more than 2 million patients collected across the country between 2005 and 2025

These studies establish SGLT-2i as a cornerstone therapy for HF across the disease spectrum (54, 61)