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Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

Yao A, Storr SJ, Inman M, Barwell L, Moody CJ, Martin SG

While oxidation is a normal process, excessive oxidative stress can be a precursor to several diseases , including: Diabetes Cancer Rheumatoid arthritis In this context, glutathione stands out for its antioxidant properties

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Interestingly, NAC exerts a GSH-supplementing effect in GSH-deficient cells, whereas this effect may be ineffective in GSH-enriched cells [101]

Biochim Biophys Acta 1839, 112