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Retatrutide : This triple agonist (GLP-1 + GIP + glucagon) produced 28.7% weight loss in Phase 3 but introduced a new safety signal: dysesthesia (abnormal skin sensations) in 4.4 to 20.9% of participants at the 12 mg dose depending on trial population
The climbing demand for these drugs driven by expanded indications and increasing off-label use for cosmetic weight loss, led to insurmountable shortages on the market
Another important consideration is patient perception
Does L-Glutamine help with muscle gain
According to altRx's published disclosure: "Compounded GLP-1s are produced in FDA-regulated facilities
Int Immunol (2018) 30(3):1139
