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However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance

4.1 Glycaemic control outcomes Meta-analyses indicate that once-weekly GLP-1 receptor agonists provide more HbA1c reduction than twice-daily exenatide, with effectiveness similar to that of daily liraglutide (Xue et al