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While animal studies suggest safety, long-term human studies are lacking

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doi: 10.1177/15353702221076397 15 HuHChenYJingLZhaiCShenL

The simplest way to think about them is in two buckets: stomach symptoms during dose escalation, and a separate skin-sensation signal at the highest dose in Phase 3

The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

Several key scRNA-seq studies have delineated diverse TAM populations in ovarian cancer, revealing novel macrophage states and their functional implications