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62 Two double-blind RCTs investigated the effectiveness of B12 in adults who had been suffering from low back pain for more than 6 months, and both found significantly better pain reduction in the B12 compared with the placebo group
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4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency
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