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PMID 37973897
Neurology (2023)
Benefits depend on candidacy, dosing, and consistency, and they are evaluated with lab work over time
Combining pulldown experiments and functional assays to identify senolytic targets To identify the targets responsible for their senolytic activity, we synthesized two alkynylated derivatives of each compound, which we used to perform target identification in competitive, protein-directed activity-based protein profiling (ABPP) experiments (Fig
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