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Retatrutide produces higher rates of nausea (43% vs 20-47%), diarrhea (33% vs lower), and vomiting (21% vs lower) at their respective maintenance doses
This strongly indicates that dysfunction of the cancerous liver has markedly reduced the first-pass elimination and as a result, there is substantial accumulation
What is the mechanism
Retatrutide: Single Molecule Advantage Simplicity: One molecule, potentially simpler manufacturing and quality control
2b and 5i,s, Extended Data Figs
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