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Whether GLP-1 medications have direct effects on testosterone production independent of weight loss is an active area of investigation
BranisteanuDEPirvulescuRASpinuAEPorumbEACojocaruMNicolescuACet al
1981, pp
These include other FDA-approved weight management medications such as phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), or orlistat (Xenical, Alli), though these agents generally produce less weight loss than GLP-1 medications
10.1016/s0140-6736(64)90011-x 53 MooreB
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