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Some clock genes are reported to directly bind the SOD1 promoter, enhancing nocturnal antioxidant defense, or regulate NADPH-generating enzymes to maintain rhythmic reducing power [139]
Folmer, H
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In a primary prevention study among 3,629 cognitively healthy older adults, the Prevention of Alzheimers Disease by Vitamin E and Selenium (PREADViSE) trial, vitamin E supplementation (400 IU/day of supplemental all - rac --tocopheryl acetate [180 mg/day of RRR --tocopherol]) for a mean of 5.4 years had no benefit on prevention of dementia (113)
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Direct glutathione testing is available but not commonly ordered
