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Furthermore, a therapy with dipyridamole, which is now recognized as a potent antioxidant, can prevent the development of early atherosclerotic intimal lesions (which are composed of proliferating smooth muscle cells surrounded by large amounts of collagen, elastic fibers, and glycosaminoglycans) that are observed in hyperhomocyst(e)inemic baboons (Harker et al, 1976)
Reactive chemical forms, such as free radicals, can oxidize low-density lipoproteins producing oxy-cholesterols and oxidized fats and proteins within developing arterial plaques
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S., Thim, L., Madsen, K
Biotransformation can temporarily increase reactivity
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