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A metabolism-focused framework can help regulators and investigators by making the therapeutic claim testable: the product should have a defined metabolic target, a reproducible potency assay, a biologically plausible delivery window and biomarkers showing that the target changed in treated patients
Pharmaceutical Research, 16(9), 14121416
NAC was dosed at 200 or 300 mg/kg via intraperitoneal injection at 1 h after treatment with 600 mg/kg APAP
Both AOD9604 and hGH were found to increase 3-AR mRNA expression, as well as protein levels and functional activity, in mouse and human cell lines in vitro
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