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The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
For simplicity, we assume that the activations of GCL and GPX are equal, though that may not be the case
Until further evidence is published, we limit performing laser treatment of CMN
The STEP-HFpEF results demonstrate a trend towards reduced incidence of AF in the study group
Phentermine, a primary aliphatic amine, cannot undergo deamination as the -carbon does not contain hydrogen and the drug is therefore N-hydroxylated
& Isaacs, J
