Fluoxetine administration to treat depression during pregnancy has been shown to induce greater changes in gene expression in the placenta of male infants than in that of female infants, emphasizing its sex-specific effects (Staal et al., 2024)
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GOx-Mn/HA coordinated two synergistic enzymatic functions: i) GOx initiated substrate depletion by converting glucose to gluconic acid with concomitant HO production
Finally, these observations provide a unique example of an intervention which appears to favor female healthspan and lifespan, thereby reinforcing the need for considering sex differences in devising therapeutic strategies to treat aging and its diseases