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doi: 10.1007/s11064-020-03080-5 30 KumarB

Systemic corticosteroids (prednisone) may be used for more extensive disease, though they are not appropriate for maintenance due to significant adverse effects with prolonged use

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Therefore, it is hypothesized that ghrelin synthesized within the hypothalamus, as opposed to gut-derived ghrelin, is the mediator of central orexigenic effects of ghrelin, although further research is needed 224