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The exposure of plants to environmental stress conditions like high light leads to very quick oxidation of AsA to MDHA in chloroplast (Polle, 2001)
It also plays a crucial role in the production of endothelium-derived relaxing factor (EDRF) , primarily nitric oxide
If you have been on a stable dose and suddenly notice your appetite returning stronger than usual, storage-related potency loss could be the cause
Mitochondrial dysfunction Mitochondria are involved in neuronal activity, important for synaptic function [9], Ca 2+ signaling [46, 91], generation of action potentials [158] ion homeostasis [30, 53] and ATP synthesis
As it doesnt have FDA approval, it may have limited availability
However, 'safe' in this context requires careful qualification
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