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The post-discontinuation phase remains the least investigated, although extension studies consistently show that weight regain occurs rapidly, with patients regaining up to two-thirds of the lost weight within one year after withdrawal (22)

We treated the MOLP-8 myeloma cell line with increasing concentrations of the ERK5-CHAMP RNK06138 for 24 h and observed a dose-dependent decrease in ERK5 protein levels with a Dmax (maximum degradation) of 74% and DC 50 (half-maximal degradation concentration) of 111.7 nM

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