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GSK3 overexpression abrogates the protective effects of semaglutide, while GSK3 knockdown mimics its actions, establishing GSK3 as a mediator of GLP-1
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GPX2 is a key antioxidant enzyme involved in the detoxification of reactive oxygen species (ROS), which are known mediators of cisplatin- and 5-FUinduced cytotoxicity [17,18,19,20]
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