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Bone marrow mesenchymal stem cells (BMSCs) can differentiate into various cell types, including osteoblasts and chondrocytes
This pattern is problematic for several reasons
Fat-soluble vitamins (D3, K2, E, A, omega-3s, CoQ10) should always be taken with a meal containing fat
This can make them feel dizzy, lightheaded, or even cause them to faint
A secondary effect of this stress is activation of Nrf2 and its target genes resulting in compensatory higher GSH levels and induction of antioxidant genes in the livers of these mice, which makes these livers more resistant to additional acute stress such as APAP toxicity [151]