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In addition, hypothemycin inhibits the phosphorylation of the mitogen-activated protein kinase kinase (MEK)3/6 substrate p38, the MEK4/7 substrate c-Jun N-terminal kinase (JNK), and the TGF--activated kinase 1 (TAK1) substrate IB kinase

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The C-terminal of hormone binds to the extracellular domain, while the N-terminal interacts with the transmembrane domain of the receptor (43)