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Exploration of GSH-degrading enzyme modulators presents a promising avenue for impeding cancer progression, overcoming tumor resistance to pro-oxidative therapy and preserving tumor sensitivity to chemotherapy (Table III)
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It also upregulates growth factors, modulates inflammatory cytokines, activates FAK-paxillin signaling (which drives cell migration into injury sites), and supports collagen synthesis
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The kynurenine pathway: a finger in every pie
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