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Being water based I don't think b12 requires a large needle like some people like to use

Single Daily Dose Both once-daily and twice-daily dosing approaches have proponents in the community

10.1164/rccm.201810-1975TR 6 BirchJ.JessG

CagriSema's Advantages: First to Market: 6-12 month head start Leverages Wegovy Success: Built-in brand recognition Proven Semaglutide Component: Half the drug is already approved Strong Diabetes Data: Positions for dual indication No Dysesthesia: Cleaner safety profile in one key area Retatrutide's Advantages: Higher Efficacy: 28.7% vs 20.4% (8.3 points more) Superior BP Reduction: -14 mmHg vs likely similar to semaglutide Single Molecule: Potentially easier manufacturing Multiple Indications: OA, OSA, obesity, diabetes trials Novel Class: First triple agonist = strong IP protection The Verdict: Market Will Support Both These medications won't compete head-to-head

Having said that lets talk about the best tests to order to identify vitamin B12 deficiency

What is actually in the vial is its own separate gamble