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The extracellular matrix components affect growth, differentiation and mobility of stem cells through a multitude of peptide regulators, adhesions molecules, growth factors and transcriptional factors [ 14 ]

Ipamorelin was created and patented by Novo Nordisk and Helsinn Therapeutics in 1994, and designed to emulate ghrelin's role in the gastrointestinal tract to enhance peristalsis [7]

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