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To understand the dynamics of this interplay in T1DM, one must go back to the relation between portal insulin and GHR expression on hepatocytes, which was so cleverly addressed by Leung et al

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To clarify the involved signalling pathways, cells were incubated with AICAR (0.5 mmol/L), compound C (10 mol/L), exendin (939) (200 nmol/L) or H89 (10 mol/L) for 30 min before other treatments

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High manufacturing standards contribute to improved reliability during laboratory investigations where reproducibility is essential

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