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doi: 10.2903/j.efsa.2012.2676 20

Concurrently, its activation of the RhoA/ROCK signaling pathway induces robust contraction of the endothelial actin-myosin cytoskeleton, resulting in enlarged intercellular gaps and thereby collectively exacerbating vascular hyperpermeability, ultimately leading to severe vascular leakage and cerebral edema (107)