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Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

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However, Se has a narrow range of safety intake, because of the risk of acute and chronic toxicity (selenosis) and its potential carcinogenicity (51)

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

One early-phase safety trial was registered but results have not been publicly reported

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