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As GLP 1 receptor activation increases step by step, the brain and digestive tract recalibrate together

L.Batinic-HaberleI.LyerlyH

This mechanism distinguishes it from semaglutide, which primarily targets GLP-1, and tirzepatide, which targets GLP-1 and GIP

doi:10.1007/s42000-019-00093-w Van de Laar FA, Lucassen PL, Akkermans RP, et al

GLP-1 plays a role in regulating both appetite and blood sugar levels in response to food

Accordingly, we anticipate that the many members of this drug class (including various dual- and tri-agonists) currently under development will continue to drive adverse effects disproportionately in women