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But in general, turning a peptide (including GLP-1 or insulin) into an oral formulation means overcoming three major challenges: protecting the peptide from digestion in the stomach, improving absorption of the peptide via the gut, and slowing down the enzymatic breakdown and excretion of the peptide once it is in the blood

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There is also some evidence that GLP-1 receptor agonists can be used alongside metformin safely, although long-term data is still evolving

It affects 69% of women before menopause

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