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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
This is because higher doses can lead to a stronger immune response or greater interaction with other medications, both of which can cause itching
Compounders may develop individualized versions of GLP-1s (which is what Strive makes) that have slight formulation changes when medically necessary
Novo Nordisk leads with Ozempic, which commands nearly one-third of the market ( 31.5% ), followed by Eli Lillys Mounjaro at 23.4%
Guide to the processes of technology appraisal NICE
51 The latter also reduces macrophage accumulation and increases the collagen content of aortic plaques
