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Regulatory Peptides 128: 87-91, 2005 [ Links ] 5
Human trial Research Disclaimer: Doses reported below are from published preclinical research protocols
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The SURMOUNT-5 trial in 2025 showed an average 20.2% body weight reduction, outperforming GLP-1-only medications in direct comparisons
Thats not because they failed. Its because hunger signaling often returns when the medication is removed, and the body tends to defend its prior weight
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